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Diclofenac Sodium is a potent NSAID with anti-inflammatory, analgesic, anti-rheumatic, and antipyretic properties. It also has a mild uricosuric effect. Diclofenac works by inhibiting prostaglandin biosynthesis, reducing inflammation, pain, and fever. It is rapidly absorbed from the gastrointestinal tract when taken with or after food, reaching peak plasma levels in about 2 hours. The drug is highly protein-bound (99.7%), metabolized in the liver, and undergoes first-pass metabolism.
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✅ Description:
Moov is recommended for managing pain and inflammation across various medical fields:
🔹 Rheumatology: Used in inflammatory and degenerative rheumatic conditions such as chronic involutive polyarthritis, ankylosing spondylitis, osteoarthritis, spondyloarthrosis, acute gout, and peri-articular rheumatic disorders.
🔹 Surgery & Traumatology: Effective for treating sprains, bruises, dislocations, fractures, soft tissue injuries, and post-surgical pain and swelling.
🔹 Obstetrics & Gynecology: Helps manage pain and inflammation associated with primary dysmenorrhea, episiotomy, adnexitis, endometritis, parametritis, salpingitis, and mastitis.
🔹 Otorhinolaryngology (ENT): Used as a pre-operative medication to prevent pain, inflammation, and swelling.
🔹 Dentistry: Helps relieve post-operative and post-traumatic pain, swelling, and inflammation.
🔹 Other Uses: Provides pain relief and reduces inflammation for patients undergoing urogenital tract surgery and those experiencing renal or biliary colic.
Use as directed by a licensed medical professional.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ 📌 Diclofenac Gel (Topical Use Only):
- Apply 2-4 g of gel 3-4 times daily, depending on the size of the affected area.
- Rub gently onto the skin.
- Can be used alongside other Diclofenac dosage forms.
✔️ 📌 Diclofenac Injection:
- Adults: 1 ampoule per day, with a maximum of 2 ampoules daily in severe cases.
✔️ 📌 Diclofenac Suppository:
- Adults: 50 mg suppository 2-3 times daily, with a maximum dose of 150 mg per day.
✔️ 📌 Diclofenac TR Capsule:
- Adults: One capsule daily, preferably after meals.
✔️ 📌 Diclofenac Dispersible Tablet (DT):
- Adults: 2-3 tablets per day, with a maximum of 150 mg daily. In milder cases, 2 tablets per day may be sufficient. Preferably taken before meals.
- Children: Not generally recommended, except for juvenile rheumatoid arthritis, where 1-3 mg/kg body weight per day is advised.
- To use, dissolve one tablet in half a glass of water, stir, and drink immediately. Not recommended for use beyond three months.
✔️ 📌 Diclofenac SR Tablet
- Adults: 1 tablet daily, swallowed whole with liquid, preferably with food. If needed, increase the total daily dose to 150 mg by supplementing with conventional tablets.
- Children: 1-3 mg/kg body weight per day, divided into multiple doses.
- Elderly: The lowest effective dose is recommended.
✔️ 📌 Diclofenac FC Tablet:
- Adults: 75-150 mg daily in 2-3 divided doses, preferably after meals. Reduce dose for long-term use.
✔️ Side Effects:
🔸 Generally well-tolerated, but some patients may experience:
- Digestive issues (epigastric pain, nausea, belching, diarrhea).
- Headache or dizziness at the start of treatment.
- Peripheral edema & skin reactions (rash, eczema).
- Localized irritation with the gel formulation, including redness and rash.
✔️ ⚠ Possible interactions with:
- Lithium & Digoxin: May increase their plasma levels.
- Anticoagulants: May elevate the risk of bleeding when used with blood thinners.
- Antidiabetic Agents: Can be taken with oral antidiabetics without altering their effect.
- Cyclosporin: Increased risk of kidney toxicity.
- Methotrexate: Risk of severe toxicity if taken within 24 hours of Diclofenac.
- Quinolone Antibiotics: May lead to convulsions when combined with NSAIDs.
- Other NSAIDs & Steroids: Co-administration may heighten the risk of side effects.
- Aspirin: May lower Diclofenac's plasma levels, though the clinical impact is unclear.
✔️ 🚫 Do not use in patients with:
- Allergy to Diclofenac or any of its components.
- Peptic ulcers or gastrointestinal bleeding.
- Asthma, urticaria, or acute rhinitis triggered by aspirin or NSAIDs.
- Occlusive (airtight) dressings when using the gel formulation.
✔️ Pregnancy & Lactation:
🤰 Use only when necessary during pregnancy, at the lowest effective dose.
- Avoid during the first trimester due to insufficient safety data.
- Diclofenac may pass into breast milk, but in negligible amounts that are unlikely to harm the infant.
- The gel formulation is not recommended during pregnancy due to a lack of data.
✔️ Precautions & Warnings:
⚠ Gastrointestinal Risk: Rare cases of peptic ulcers or GI bleeding may occur.
⚠ Elderly Patients: Require close monitoring.
⚠ Topical Gel: Avoid contact with eyes, mucous membranes, or open wounds. Wash hands thoroughly after use and do not ingest.
✔️ Storage Conditions:
✔ Store in a cool, dry place, away from direct light.
✔ Keep at temperatures below 30°C.
✔ Keep out of reach of children.
